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Be Here for the Cure

The first generation of people who could live in a world free of HIV is on the planet. For the first time in history, global scientific leaders agree it is possible to cure AIDS. Several people have been cured through extraordinary measures. Now, a cure that can be more easily and widely applied must be found.

Being “here for the cure” means two main things:

  1. Supporting research scientists as they close in on the cure—and finish the fight started by Dr. Mathilde Krim and Elizabeth Taylor when they founded amfAR more than 25 years ago.
  2. Knowing your HIV status and seeking care and treatment so if you are living with HIV you can ensure you stay healthy—and are here when the cure is found.

The following are some key commonly asked questions about the AIDS cure and their answers.

  1. Why Do We Need a Cure for HIV/AIDS? Isn’t The Medicine Effective?
  2. Is It True Some People Have Been Cured?
  3. What Types of Cure Are Being Pursued?
  4. What’s the Latest Cure News?
  5. How Can I Be Here For The Cure?

1. Why Do We Need a Cure for HIV/AIDS? Isn’t The Medicine Effective?

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AmfAR’s research has led to the development of effective anti-retroviral HIV treatment. These medicines keep people with HIV healthy (so their HIV infection doesn’t turn into AIDS); they prevent the spread of the virus from mother-to-child (so babies are born HIV-free); and they double as prevention in people living with the virus as they can reduce the chance of transmission to non-affected people by 96%.

Treatment can also serve as prevention in people not living with HIV. When taken within 72-hours after potential exposure to the virus, HIV treatment can prevent transmission. This tactic is called “PEP” for “post-exposure prophylaxis.” For more information: http://1.usa.gov/1aLA6Ve. And, new data show that taking treatment prior to exposure to HIV can also reduce one’s risk of contracting the virus. This approach is called “PrEP” for pre-exposure prophylaxis (many factors impact the percent of risk reduction; the results in studies have ranged from a 44%-90% reduction of risk). For more information: http://1.usa.gov/17jbSzA. Finally, when pregnant, HIV-positive women and their newborn babies are given antiretrovirals, the risk of mother-to-child transmission of the virus can be all but eliminated.

Since antiretroviral treatment can prevent the spread of HIV, scientists wondered if it was possible to end the AIDS pandemic through treatment alone.

Their conclusion? No.

There are three main reasons:

  1. Too few people globally are on treatment. Of the 35.3 million people estimated to be living with HIV, only about 9.7 million currently have access to treatment.
  2. Many people don’t know their HIV status (including 20% of all people living with HIV in the U.S.) And, there is a “window period” between when people first contract HIV and when they will test positive for the antibodies to the virus. If people are tested in this “window period” they could get a false negative test result but still be positive. Therefore, there could always be people living with the virus who aren’t aware they have it unless they are repeatedly tested.
  3. The stigma surrounding HIV makes people, understandably, afraid to get tested and treated for HIV.

So, getting all people with HIV around the world to be aware of their status before they unwittingly pass the virus to others, and providing and paying for treatment for the remaining 25.6 million men, women and children with HIV is a real challenge and an incredible expensive. Even if it could be done, the medications have some serious side effects. Therefore, the optimal solution to HIV is a cure.

Until we have a cure, and likely for years after while we work to get people cured, efforts to prevent the spread of HIV (including the pursuits of HIV vaccines) and programs to test and treat as many people as possible must continue.

But one thing is certain: Without a cure, AIDS will never end.

The good news is there has never been a more exciting or promising time in AIDS cure research. In the last twelve months, multiple, significant scientific breakthroughs related to an AIDS cure have been made.

2. Is It True Some People Have Been Cured?

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Yes. As of July 2013, 18 people have been declared functionally cured of HIV.

AmfAR’s research supported four of these cases. All four were American. The first was Timothy Brown, known as The Berlin Patient (as he was cured while living in Germany by Gerald Hutter, a German oncologist). HIV was eradicated from his body through a stem cell transplant using cells immune to HIV. You can read his story here: http://bit.ly/13fb5v9. The second was a young child in Mississippi, who was given medication shortly after being born with HIV. Read her story here: http://nyti.ms/15rOhvL. The other two cases were two men who were also cured through a stem cell transplant, but using cells not immune to HIV. Read their stories here: http://bit.ly/13fbmhD.

Shortly after the news of the pediatric cure case, news of a French cohort of 14 patients believed to be functionally cured of HIV hit the news. Read about the French patients here: http://bit.ly/Z2EjLO.

While none of the ways these various patients have been cured is easily or safely replicable, AIDS cure research scientists are working to translate the insights from these recent cases into a cure that will hopefully work for many.

3. What Types of Cure Are Being Pursued?

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In the most fundamental sense, there are two basic types of AIDS cure: a functional cure and a sterilizing cure.

The definition of a “functional HIV cure” is that people living with the virus no longer have to take medicine and they remain healthy and non-infectious, whether or not every trace of HIV has been removed from their body.

A “sterilizing” cure is one that removes all traces of HIV from a person’s bodies.

While there is scientific agreement that the 18 aforementioned people may have been functionally cured, the jury is still out on whether any of these patients have also experienced a “sterilizing” cure.

To read about the various ways people have been cured, read “Three Types of HIV Cure” by Dr. Rowena Johnson, vice president and director of research for amfAR here: http://bit.ly/138wgne.

When might we have a cure for everyone?

While no one can say for certain, the recent spate of cures has shed significant light on AIDS cure research and greatly accelerated the hunt for the cure.

It could be closer than many realize.

Leading scientists around the world agree a cure for HIV is possible in our lifetimes.

Dr. Francoise Barre-Sinoussi, Director of the Louis Pasteur Institute in France and the winner of the Nobel prize in 2008 for her co-discovery of HIV with her colleague Luc Montagnier said, on CNN, “What we are sure is that we think it's reasonable today to say it's feasible to have a cure. A functional cure. I believe that if we work like in the early years of HIV, all together, we can move forward very fast as well for an HIV cure."

4. What’s the Latest Cure News?

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A selection of some recent, key articles focused on the AIDS cure:

Patients HIV-free For Now After Transplant, by Saundra Young. CNN

http://bit.ly/19Y2Mxi

HIV Cure “Within Months?” Not So Fast, Foundation for AIDS Research Warns, by Kevin R. Frost, The Huffington Post

http://huff.to/133XJ7T 

Cured of AIDS? Not Yet. By Donald G. McNeil Jr., The New York Times

http://nyti.ms/1bncWrM

A Cure for HIV is A Long Way Off. But We’ll Keep Looking, by Francoise Barre-Sinoussi, The London Times

http://thetim.es/WHiD7Y

AIDS Could be Eliminated in Our Lifetimes, by Meera Dalal, Al Jazeera

http://aje.me/H08OeC

An Interview with Francoise Barre-Sinoussi, PhD—Pushing for Better Coordination on Cure Reasearch, by amfAR’s Treat Asia Report

http://bit.ly/18FMJUy

Cure for AIDS Possible Says Nobel Prize-Winning Scientist Who Helped Discover HIV, The Telegraph

http://bit.ly/15uNL0h

Francoise Barre-Sinoussi: The HIV Hunter, by Andrew Jack, FT Magazine

http://on.ft.com/138EID2

The Cure Hunter, by Regan Hofmann, POZ

http://bit.ly/NVAqSY

5. How Can I Be Here for The Cure?

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As we mentioned, being “here for the cure” means two things: 1) supporting research scientists as they close in on an AIDS cure and 2) knowing your HIV status so if you’re living with the virus you can connect to care to  ensure you stay healthy enough to be here when the cure is finally here.

To support the scientific hunt for the cure, click here to go to our "Take Action" page which will direct you to ways to get engaged.

As for knowing your status, HIV testing is quick, painless and can be free and anonymous. There is now an over-the-counter HIV test that you take by running a plastic swab over your gums that can give you a result in 20 minutes in the privacy of your home. It’s called the “OraQuick ADVANCE Rapid HIV ½ Antibody Test,” is made by Orasure Technologies and is available at drugstores around the U.S. Its results do need to be confirmed by professional blood work. For more info on the test: http://bit.ly/2Rcuz.

To find a place to get tested for HIV, visit http://www.AIDS.gov.

If you discover you are living with HIV, be aware that it has been proved that starting medications earlier than previously thought increases your chances for health and survival. The World Health Organization (WHO) released their revised global guidelines for HIV treatment in July of 2013. See the new guidelines here: http://bit.ly/17LeJWa.

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